Donor aortic root dilation
نویسندگان
چکیده
منابع مشابه
Angiotensin II blockade and aortic-root dilation in Marfan's syndrome.
BACKGROUND Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by excessive signaling by transforming growth factor beta (TGF-beta) that can be mitigated by treatment with TGF-beta antagonists, including angiote...
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Aortic root dilation is an important, potentially lethal omplication of BAV (4) that substantially increases the risk f ascending aortic aneurysm, dissection, and rupture (3). uriously, aortic valve replacement does not prevent proressive dilation of the ascending aorta (5), suggesting that echanisms unrelated to hemodynamic factors, or to the alve per se, contribute to the aortopathy of BAV. A...
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BACKGROUND Neo-aortic root dilation (ARD) and neo-aortic regurgitation (AR) may be progressive after arterial switch operation (ASO) for d-loop transposition of the great arteries (dTGA). We sought to identify predictors of ARD and AR after ASO. METHODS AND RESULTS 335 patients were identified who underwent ASO for dTGA with intact ventricular septum or ventricular septal defect (VSD), includ...
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BACKGROUND The sequelae of aortic root dilation are the lethal consequences of Marfan syndrome. The root dilation is attributable to an imbalance between deposition of matrix elements and metalloproteinases in the aortic medial layer as a result of excessive transforming growth factor-beta signaling. This study examined the efficacy and mechanism of statins in attenuating aortic root dilation i...
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Background—Few data are available that address the impact of athletic training on aortic root size. We investigated the distribution, determinants, and clinical significance of aortic root dimension in a large population of highly trained athletes. Methods and Results—Transverse aortic dimensions were assessed in 2317 athletes (56% male), free of cardiovascular disease, aged 24.8 6.1 (range, 9 ...
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ژورنال
عنوان ژورنال: Canadian Journal of Cardiology
سال: 2009
ISSN: 0828-282X
DOI: 10.1016/s0828-282x(09)70108-4